Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard of care for Grinder advanced non-small-cell lung cancer (NSCLC) patients.However, most patients will eventually develop resistance.For EGFR-TKI resistance mediated by MET amplification, the combination of EGFR and MET TKIs has shown promising results in early

Increased loading rates on fasteners may be caused by high ground accelerations as a consequence of e.g., nuclear explosions, earthquakes or car collisions.It was concluded by Hoehler et al.(2006) that fasteners under rapid loading rates show an increased ultimate resistance in the concrete dominant failure modes or the ultimate resistance is at le

The body-specificity hypothesis (BSH) predicts that right-handers and left-handers allocate positive and negative concepts differently on the horizontal plane, i.e., while left-handers allocate negative concepts on the right-hand side of their bodily space, right-handers allocate such concepts to the left-hand side.Similar research shows that peopl

Simultaneous localization and mapping (SLAM) is one of the key technologies for mobile robots to achieve autonomous driving, and the lidar SLAM algorithm is the mainstream research scheme.Firstly, this paper introduces the overall framework of lidar SLAM, elaborates on the functions of front-end scan matching, loop Wallplates closure detection, bac

Precipitation in Iceland during a period of 10 years is simulated with the PSU/NCAR MM5 model.The results are compared with precipitation estimated by a statistical model based on observations and a number of topographic and geographic predictors.The simulated precipitation pattern agrees with the statistical model in areas where data is available